Dieta Hoodia

Nakasugi, Tohru; Komai, Koichiro
Res. Lab. Med, Prod. Plant Origin
Kinki Daigaku Nogakubu Kiyo (1994), 27, 47-54

An antimutagen from Aloe Arborescens Mill was isolated and identified. Methanol exts. from dried leaves of A. arborescens inhibited frameshift mutation induced by 3-amino-1-methyl-5H-pyrido [4, 3b] indole in Salmonella typhimurium TA98. The antimutagen isolated from the methanol exts. was identified as the anthraquinone Aloe-emodin. Aloe-emodin inhibited frameshift mutation by 60.3% at 0.1 mM/plate and 86.3% at 1.0 mM/plate whereas barbaloin, monoglucoside of Aloe-emodin, did not. Fresh A. aborescens leaves contained 1.17 ug/g (wet wt.) of Aloe-emodin. Aloe-emodin was also detected in A. ferox, A. vera, A. eru, and A. compacta by HPLC. These Aloe species may have substances that are useful for prevention of some forms of cancer.