Investigaciones - Research & Papers on Aloe
Investigaciones - Research & Papers - Aloe vera - Aloe saponaria - Aloe ferox - Aloe arborescens - Aloe chinensis - Aloe socotra
Various AIDS studies were completed by researchers such as Dr. Terry Pulse, M.D., Dr. Reg McDaniel, M.D., Dr. Terry Watson, D.O., Dr. Clumeck, M.D. (of Belgium) and others throughout the 1980’s using oral mucopolysaccharides.
The results were impressive, demonstrating in many of the studies an average of 70% improvement in symptoms and laboratory criteria within 3 to 4 months. Many patients stated that opportunistic infections had stopped and they were able to return to normal activity.
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Sakai R
Department Of Epidemiology, School Of Health Sciences, Ryukyu University
Jpn J Cancer Res 80(6):513-20 1989 Jun
This case-control study of lung cancer was based on a cross-sectional questionnaire survey of inpatients at 5 general hospitals in Okinawa, Japan, from 1982 to 1987.
The purpose of the study was to clarify the relations of lung cancer to cigarette smoking and plant diet. Ingestion frequencies of 17 major dietary plants and/or herbs were obtained by means of a questionnaire interview. As eligible subjects for a case-control analysis, there were 673 respondents aged over 30 years with clear smoking history, age, sex and diagnosis. Psychiatric patients were excluded.
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Winters WD; Benavides R; Clouse WJ
Dep. Microbiol., Univ. Tex. Health Sci. Center
Econ Bot 35 (1), 1981, 89-95
Fractions of leaf extracts from 2 local types, labeled Aloe vera (subsequently identified as A. barbadensis Mill., and A. saponaria Haw.), were prepared by differential centrifugation and tested by in vitro assays for the presence of lectin-like activities and for effects on the attachment and growth of human normal and tumor cells. Fractions of extracts of fresh leaves and commercially A. vera gel had high levels of lectin-like substances measured by immunodiffusion and nemagglutination assays. Substances in fluid fractions from both fresh leaf sources markedly promoted attachment and growth of human normal cells.
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Gribel’ NV; Pashinskii VG
Vopr Onkol 32(12):38-40 1986
An evaluation of antimetastatic properties of succus Aloes was carried out using three types of experimental tumors of mice and rats. It was found that succus Aloes treatment contributes to reduction of tumor mass, metastatic foci and metastasis frequency at different stages of tumor progress without affecting major tumor growth. Succus Aloes potentiates the anti-tumor effect of 5-fluorouracil and cyclophosphamide as components of combination chemotherapy.
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Plant Lectin, ATF1011, On The Tumor Cell Surface Augments Tumor-Specific Immunity Through Activation Of T Cells Specific For The Lectin
Yoshimoto R; Kondoh N; Isawa M; Hamuro J
Cancer Immunol Immunother 25(1):25-30 1987
The possibility that a plant lectin as a carrier protein would specifically activate T cells, resulting in the augmentation of anti-tumor immunity was investigated. ATF1011, a nonmitogenic lectin for T cells purified from Aloe arborescens Mill, bound equally to normal and tumor cells.
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Desai KN; Wei H; Lamartiniere CA
Department Of Pharmacology & Toxicology, University Of Alabama
Cancer Letters 101(1):93-6 1996 Mar 19
Recent scientific evidence has shown free radicals or reactive oxygen species (ROS) to play an important role in the initiation and progression of cancer. Many radical scavengers have also been found to help reduce the attacks by these ROS. Interestingly, the ROS scavengers that have been investigated are naturally occurring compounds such as vitamins C and E. Roidex is a formulation of squalene, vitamin E, and Aloe vera.
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Winters
Health Science Center, University Of Texas
In 1977 while conducting a series of animal experiments using aloemannan a mucopolysaccharide of Aloe arborescens, detected aloemannan a significant antitumor efficacy. Unlike usual anticancer drugs killing cancer cells directly, it acts as a stimulus for the body’s defense mechanism, or immunity to suppress tumor. In other words, it prohibits multiplication of cancer cells while it is coexistent with them. Prof. Winters and his group of the Health Science Center at the University of Texas verified their test-tube experiments using human cervical cancer cells that Aloe vera extract prohibits the growth of cancer cells.
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Nakasugi, Tohru; Komai, Koichiro
Res. Lab. Med, Prod. Plant Origin
Kinki Daigaku Nogakubu Kiyo (1994), 27, 47-54
An antimutagen from Aloe Arborescens Mill was isolated and identified. Methanol exts. from dried leaves of A. arborescens inhibited frameshift mutation induced by 3-amino-1-methyl-5H-pyrido [4, 3b] indole in Salmonella typhimurium TA98. The antimutagen isolated from the methanol exts. was identified as the anthraquinone Aloe-emodin. Aloe-emodin inhibited frameshift mutation by 60.3% at 0.1 mM/plate and 86.3% at 1.0 mM/plate whereas barbaloin, monoglucoside of Aloe-emodin, did not. Fresh A. aborescens leaves contained 1.17 ug/g (wet wt.) of Aloe-emodin. Aloe-emodin was also detected in A. ferox, A. vera, A. eru, and A. compacta by HPLC. These Aloe species may have substances that are useful for prevention of some forms of cancer.
Jeong HY; Kim JH; Hwang SJ; Rhee DK
Coll. Pharm., Sung Kyun Kwan Univ.
Yakhak Hoeji 38 (3). 1994. 311-321
Anticancer effects of Aloe on sarcoma 180 in ICR mouse or human cancer cells were determined. Sarcoma 180 cells were inoculated subcutaneously into male ICR mouse to determine effect of Aloe on tumor growth, or inoculated intraperitoneally into male ICR mouse to determine effect of Aloe on life span prolongation, followed by oral administration of Aloe vera (10 mg/kg/day, 50 mg/kg/day) or Aloe arborescens (10 mg/kg/day, 100 mg/kg/day) once a day for 14 days.
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Tizard I; Kemp M
Texas A&M
Research by the immunologist Ian Tizard, Ph.D. and virologist Maurice Kemp, Ph.D. from Texas A&M led to the discovery that Aloe mucopolysaccharide is taken into a special leukocyte, the macrophage, and this cell is stimulated to release messenger molecules called cytokines (interferons, interleukines, prostaglandins, tumor necrosis factor and stem-cell growth factors.) Tumors release a chemical that attracts blood circulation so that malignant cells have a supply to the tumor and it therefore dies. All of the immune modulating effects from Aloe contribute greatly to the prevention and healing of malignant cells.
Kupchan SM, Karim A.
A systematic fractionation of an ethanol-water (1:1) extract of the seeds of Rhamnus frangula L., guided by assays for tumore-inhibitory activity, led to the isolation of aloe emodin (1). This compound was found to show significant antileukemic activity against the P-388 lymphocytic leukemia in mice. A note-worthy vehicle-dependence of the testing results is reported. In the light of this vehicle-dependence, the re-examination of other anthraquinone derivatives is recommended.
PMID: 957911 [PubMed - indexed for MEDLINE]
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By Lawrence Plaskett, B.A., Ph.D., C.Chem., F.R.I.C.
Aloe Vera contains Glucomannan, a special complex polysaccharide composed largely of the sugar mannose. It interacts with special cell-surface receptors on those cells which repair damaged tissues, called fibroblasts, stimulating them, activating their faster growth and replication. Plant hormones in Aloe, called gibberellins, also accelerate healing by stimulating cell replication. These combined actions make Aloe a uniquely potent healing Herb.
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ScienceDirect - International Immunopharmacology
Mannan from Aloe saponaria inhibits tumoral cell activation and proliferation
International Immunopharmacology
Volume 4, Issue 3 , March 2004, Pages 411-418
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Trabajos de investigación relacionados con propiedades farmacéuticas y cosmetológicas del aloe saponaria
1. Trabajo original, idioma inglés
Source: J Pharm Sci 1984 Jan;73(1):62-5
Title: Structure determination of polysaccharides in Aloe saponaria (Hill.) Haw. (Liliaceae).
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