Dieta Hoodia

Is P57 a Cardiac Glycoside?

MacLean DB and Luo LG, two researchers at the Division of Endocrinology, Hallett Center for Diabetes and Endocrinology, Brown Medical School, were intrigued by the fact that P57 is chemically similar to a class of plant-derived compounds called cardiac glycosides, of which the ones derived from various foxglove species (genus Digitalis) are the best known.

These powerful drugs increase the force of contraction of the heart muscle and help maintain normal heart rate and rhythm. A common side effect of the cardiac glycosides is loss of appetite.

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Hoodia Gorodonii Research - Clinical Studies

Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside

David B. MacLean and Lu-Guang Luo

Division of Endocrinology, Hallett Center for Diabetes and Endocrinology, Brown Medical School, Coro Building, Providence, RI 02903, USA

Accepted 1 April 2004.  Available online 20 July 2004.

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Obesity may contribute to type 1 diabetes, say scientists

Obesity has long been recognized as a cause for type-2 diabetes, but scientists now say that the disease may be a factor in accelerated type-1 diabetes in some children.

The new research, published in the February issue of Diabetes Care, may lead to more pressure being placed on food manufacturers, already under fire for the rising incidence of childhood obesity.

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A growing number of women are overweight or obese when they become pregnant

STUDY - OBESITY - OVERWEIGHT - PREGNANT - RISK - BABY - WEIGHT LOSS

A study conducted by researchers at the University at Buffalo ( UB ) has shown.that a growing number of women are overweight or obese when they become pregnant, a condition that is risky to both mother and baby.

An analysis of the prepregnancy body mass index ( BMI ) of more than 79,000 women in eight counties of Western New York who became pregnant between 1999 and 2003 found that the number of women who were overweight when they became pregnant increased by 11 percent and the number who were obese increased by 8 percent over that time period.

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Middle-age obesity raises risk later

WASHINGTON -- Obesity in middle age substantially increases the risk of dying of heart disease later in life, even for those who have normal blood pressure and cholesterol levels, a study has found.

The report by Northwestern University researchers, published in yesterday's issue of the Journal of the American Medical Association, found that obese adults ages 33 to 65 have a 43 percent higher risk of dying from coronary heart disease after age 65 than those of normal weight in the middle-age bracket.

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New Study Links Obesity, Heart Problems

By LINDSEY TANNER, AP Medical Writer

CHICAGO - Middle-age people who are overweight but have normal blood pressure and cholesterol levels are kidding themselves if they think their health is just fine.

Northwestern University researchers tracked 17,643 patients for three decades and found that being overweight in mid-life substantially increased the risk of dying of heart disease later in life — even in people who began the study with healthy blood pressure and cholesterol levels.

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UK - Overweight people not interested in healthy lifestyle

According to a poll in the UK more than a quarter of obese and overweight people do not want to lose weight, and many were unable to identify their weight category.

The survey by Cancer Research UK also found many more were unaware of the benefits of a healthy lifestyle and that being overweight increased their risk of cancer.

The findings coincide with the charity and Weight Concern publication of 10 tips to help people manage their weight.

They include keeping regular meal times, walking 10,000 steps a day and snacking healthily.

Although more than half of the 4,000 people polled were overweight or obese, 26% of them said they did not want to lose weight.

Of even more concern was that as many as 87% of obese and 32% of overweight people were unable to identify their weight category.

Three-quarters said they did not know there was a link between cancer and weight and nearly half did not believe eating healthily could reduce cancer risk.

Obesity is linked with an increased risk of bowel, kidney, oesophageal and stomach cancers, as well as cancer of the womb and breast cancer in post-menopausal women.

Dr Lesley Walker, director of cancer information at Cancer Research UK, says it is a cause for concern that so many people are in denial about their weight, as those who carry extra weight face significant health risks including cancer.

Dr Walker says that obesity is one of the biggest known preventable causes of cancer for those who do not smoke.

Weight Concern executive director Caroline Swain is reported to have said that the lack of concern about obesity was a worry and education and support were vital in tackling the alarming rise in obesity.

The organisation advises people to keep to a meal routine, choose reduced fat versions of food, pack a healthy snack and always watch portion size as well as fat and sugar content of foods and drinks.

They advise drinking water and remembering that alcohol is high in calories.

Eat food slowly they say and include at least five portions of fruit and vegetables each day.

Source: News-Medical.Net

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Posted in Research & Papers on Hoodia - Obesity - Overweight 703 lecturas

Health risks of obesity going unnoticed

More than a quarter of obese and overweight people in the UK do not want to lose weight and many are unaware of the risk of cancer, a new poll has shown.

A report by Cancer Research UK reveals that 87 per cent of obese people and 32 per cent of overweight people surveyed were unable to identify their correct weight category. The survey found that 71 per cent of those at risk because of their weight were unaware that being obese or overweight increases cancer risk.

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Study: Obesity may hinder prostate diagnosis

CHARLOTTE, North Carolina (AP) -- Obese men face an increased risk of dying from prostate cancer and doctors should be especially thorough when checking these patients for the disease, a new study suggests.

Because the size of the prostate gland is larger in obese men, prostate cancer can be 20 percent to 25 percent harder for doctors to detect, according to Dr. Stephen Freedland, a surgeon at Duke University Medical Center in Durham and lead author of the study.

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Lifestyle modification should be the first line of treatment for obesity

OBESITY - STUDY - WEIGHT LOSS - DIABETES - DIETS

A new study shows that treatment with a lifestyle modification program of diet, exercise and behavioral therapy when used in combination with the weight loss medication sibutramine (Meridia) resulted in significantly greater weight loss among obese adults than treatment with the medication alone.

The study, conducted by researchers from the University of Pennsylvania, appears in the the New England Journal of Medicine and was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

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Obesity may affect memory in diabetics

OBESITY - DIABETICS - MEMORY - STUDY - RISK

PETERBOROUGH -- Obesity could lead to impaired memory for people with Type 2 diabetes, a study by a Trent University research team suggests.

The team studied the effects of high-fat diets and obesity on learning and memory using rats as the model, said lead investigator Dr. Gordon Winocur.

"We have been finding some significant changes in their ability to learn new tasks and remember new information," said Winocur, a Trent psychology professor and senior scientist and vice-president of research at the Rotman Research Institute at the Baycrest Centre for Geriatric Care in Toronto.

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Study Shows Correlation Between Obesity and Brain Pathways

OBESITY - CORRELATION - BRAIN PATHWAYS - STUDY - HEALTH

Boston, MA (AHN) - A study led by a scientific team at Beth Israel Deaconess Medical Center (BIDMC) provides another important step in our understanding of the critical role the brain’s molecular pathways play in the development of obesity and related disorders.

The findings identify for the first time the neuronal pathways that help keep body weight stable diverge at the melanocortin-4 receptor (MC4R) to regulate either food consumption or energy expenditure.

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Obesity linked with leukemia

OBESITY - LEUKEMIA - LINK - CANCER - STUDY - OVERWEIGHT

BEING overweight or obese dramatically increases your risk of developing myeloid leukemia, according to a study of almost 41,000 Melburnians.

Cancer Council Victoria researchers followed the group for more than eight years to find out if body size and composition were linked to cancers of the blood and lymph systems.

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Weight loss may reverse heart damage

WEIGHT LOSS - DAMAGE - HEALTH - CARDIOVASCULAR

By KARA PHILLIPS

ADELAIDE Researchers are testing the theory that losing weight can actually reverse heart damage in patients who have neglected their cardiovascular health.

A team of world class researchers at the Royal Adelaide Hospital and University of Adelaide, announced details of the groundbreaking new clinical trial at the Australasian Society for the Study of Obesity conference in Adelaide at the weekend.

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