Dieta Hoodia

OBESITY - CORRELATION - BRAIN PATHWAYS - STUDY - HEALTH

Boston, MA (AHN) - A study led by a scientific team at Beth Israel Deaconess Medical Center (BIDMC) provides another important step in our understanding of the critical role the brain’s molecular pathways play in the development of obesity and related disorders.

The findings identify for the first time the neuronal pathways that help keep body weight stable diverge at the melanocortin-4 receptor (MC4R) to regulate either food consumption or energy expenditure.

This discovery helps to extend the understanding of the complex neurocircuitry behind body weight control.

Bradford B. Lowell, MD, PhD at BIDMC says, "The brain controls both food intake and calories expended with the purpose of keeping body weight stable. When something goes wrong with this process, obesity results. The findings of this new research provide us with more precise information about the neuronal pathways regulating this balance."

The study’s lead author Nina Balthasar, PhD says, "Scientists have known that by activating MC4Rs, body weight can be reduced."

Research has shown that when all MC4 receptors are removed in gene knockout mice, the animals become morbidly obese. This process is important in people as well, because humans with defective MC4 receptors also become obese.

In this new study Balthasar and her colleagues set out to identify the exact groups of neurons responsible for producing these important effects of MC4 receptors.

These new findings help researchers refine our understanding of the neuronal logic behind body weight.

The scientists conclude. "In our present climate in which the incidence of obesity and attendant health problems is rapidly increasing, every bit of new information is key."

Source: Hall Headline News

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Posted in Research & Papers on Hoodia - Obesity - Overweight 1153 lecturas